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Please use this identifier to cite or link to this item: http://hdl.handle.net/1812/489

Title: Alkaloids isolated from litsea petiolata and phoebe tavoyana (Lauraceae)
Authors: Hanita Omar
Keywords: Alkaloidal
Phoebe tavoyana (Meissn.)
Issue Date: May-2009
Publisher: University of Malaya
Abstract: A study on the alkaloidal composition of two Malaysian plants from the family of Lauraceae i.e Litsea petiolata Hk.F and Phoebe tavoyana (Meissn.) Hk.F., has been carried out. The alkaloids were extracted with dichloromethane, whereas the isolation of the alkaloids was achieved by various chromatographic techniques such as column chromatography and preparative thin layer chromatography. A total of 14 compounds were isolated of which two are new alkaloids. The structural elucidations were carried out via spectroscopic methods; notably 1D and 2D NMR (COSY, HMQC, HMBC, NOE-DIFF), MS, IR, UV and comparison with the published data. Investigation of the alkaloidal content from the bark of Litsea petiolata afforded five alkaloids. Compounds isolated are two indole alkaloids (β-carboline) namely Harman or aribine 52, norharman 53, along with the three known isoquinoline alkaloids which normally occur in Lauraceae plant; Benzylisoquinolines: reticuline 31, aporphine: isoboldine 61; and one simple isoquinoline: thalifoline 100. β-carboline alkaloid: Harman and norharman type were isolated for the first time in the genus of Litsea. Isolation and purification of alkaloids from the bark of Phoebe tavoyana afforded 9 alkaloids of which 2 are new compounds: (+)-tavoyanine 101 and (-)-tavoyanine 102 along with four known aporphines; norboldine 77, laetanine 73, roemerine 84, boldine 74 and one morphinandienone, sebiferine 103.
Description: Dissertation (Master of science) -- Faculty of Science, University of Malaya, 2009.
URI: http://dspace.fsktm.um.edu.my/handle/1812/489
Appears in Collections:Masters Dissertations : Science

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