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Please use this identifier to cite or link to this item: http://hdl.handle.net/1812/522

Title: Synthesis, characterization and biological activities of Benzenesulfanohydrazones and their metal complexes
Authors: Laila Musalem Masi Al-Mahrouqi
Keywords: Benzenesulfanohydrazones
Metal complexes
Antiulcerogenic activity
Issue Date: Jun-2009
Publisher: University Malaya
Abstract: The Schiff bases of 2-hydroxyacetophenone benzenesulfanohydrazones and their metal complexes with Zn(II), Ni(II) and Cu(II) were synthesized. All the ligands and complexes were characterized by IR, NMR, UV spectroscopy, TGA and x-ray crystallographic techniques. From the spectroscopic and x-ray crystallographic studies showed that the ligand 2-hydroxyacetophenone benzenesulfanohydrazones form metal complexes with N, O-coordination. All the ligands and their metal complexes were tested for antiulcerogenic activity on Sprague-Dawley rats. The Schiff bases of 2-hydroxyacetophenone benzenesulfonohydrazone excellently inhibited gastric lesions on the glandular part of the stomach. It is believed that ulcer inhibition did not influence by the production of mucus and gastric juice acidity. The hemorrhagic lesions were found to be prevented even though the mucus secreted is lower than that secreted by the positive control (Cimetidine). This could explain that other mechanisms may take place during the prevention. The biological activities were ran at Molecular Medicine Department, Faculty of Medicine, University of Malaya.
Description: Dissertation -- Faculty of Science, University of Malaya, 2009.
URI: http://dspace.fsktm.um.edu.my/handle/1812/522
Appears in Collections:Masters Dissertations : Science

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