<fmt:message key='jsp.layout.header-default.alt'/>  
 

DSpace@UM >
Faculty of Science >
Masters Dissertations : Science >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1812/553

Title: The pattern of Epstein- Barr virus association in malignant lymphoma
Authors: Ahmed M.A.Alatbash
Keywords: Epstein- Barr virus
EBV
B-cell lymphoma
DLBCL
Lymphoma
Hodgkin’s lymphoma
Issue Date: Mar-2009
Publisher: University Malaya
Abstract: EBV status in patients with Classical Hodgkin’s lymphoma, T-Cell Non –Hodgkin’s lymphoma and diffuse large B-cell lymphoma (DLBCL), were investigated to define prognostic impact of Epstein- Barr virus (EBV) infection. A series of 47 cases of Hodgkin’s lymphoma, 20 cases of T-Cell non-Hodgkin‘s lymphoma and 66 cases of Diffuse Large B Cell Lymphoma was analyzed for the presence of Epstein-Barr virus (EBV) using EBER in situ hybridization. In situ hybridization showed the presence of EBV in 18 cases of Hodgkin’s lymphoma (38%) and 4 cases of T-Cell Non Hodgkin lymphoma (20%) and 5 cases of DLBCL (8%).The frequency of EBV was strongly associated with Hodgkin lymphoma more than the other type of lymphoma; also I recognized that EBV was strongly associated with Mixed Cellularity Hodgkin lymphoma Subtype, EBV was detected in the Reed Sternberg cells of mixed Cellularity subtype Hodgkin’s disease in 10 of 17 cases (59%) as compared with Nodular Sclerosis histology, in which only 5 of 21 cases (24%) were EBV-associated. Also we can recognize that EBV was shown to be strongly associated with a subset of T-NHL subtypes e.g. NK/T-cell angioimmunoblastic and T-NHL-unspecified. The lowest frequency of EBV are recognized in DLBCL in which EBV associated with only (8%) of all 66 cases.
Description: Dissertation -- Faculty of Science, University of Malaya, 2009.
URI: http://dspace.fsktm.um.edu.my/handle/1812/553
Appears in Collections:Masters Dissertations : Science

Files in This Item:

File Description SizeFormat
THESIS PART ( A ).pdfPart A65.58 kBAdobe PDFView/Open
THESIS PART ( B ).pdfPart B1.64 MBAdobe PDFView/Open


This item is protected by original copyright



Your Tags:

 

  © Copyright 2008 DSpace Faculty of Computer Science and Information Technology, University of Malaya . All Rights Reserved.
DSpace@UM is powered by MIT - Hawlett-Packard. More information and software credits. Feedback